Cadiz have gone down 2-1 to fourth-division Arandina, becoming the second top-flight team in Spain to be eliminated in the second round of the Copa del Rey.
Cadiz's elimination came a day after Almeria fell 1-0 to fourth-division Barbastro.
Jorge Pesca scored a 65th-minute winner for Arandina. The club based in Aranda de Duero, a small city in northern Spain, had never advanced past the second round.
It was the 13th game in a row without a win for Cadiz, who sit in 16th place in the Spanish league, three points from the relegation zone. They advanced in the first round of the Copa with a win on penalties against fifth-division Badalona.
Last-place Almeria lost Wednesday to remain with only one victory in 17 matches in all competitions this season - against third-division club Talavera in the previous Copa round.
Cadiz have only two wins in all competitions this season, and none since September.
First-division club Granada were also eliminated after being disqualified for fielding an ineligible player in the first round.
Australian Associated Press